The barriers with which professionals are confronted are numerous regarding freight logistics but also infrastructure and spatial development. This makes the implementation of measures not straightforward. The toolbox is a means to develop a clear mapping of barriers and measures (physical-spatial, institutional, social-economical, environmental/liveability). The toolbox is linking the different dimensions with each other to overcome ‘silo thinking’. An example are the differences in timing between (inert) infrastructures, (fast cycles in) freight and logistics, and (incremental) spatial development posing specific implementation issues to integrated solutions. This is also true for the differences in spatial level ((trans)national infra networks and freight transport vs. local spatial development and last-mile logistics) as well as differences in stakeholders involved (market, private parties vs governmental parties). Therefore, in the conceptual model explicit attention is paid to the implementation of the developed solutions for individual cases as well as of the Vital Nodes conceptual framework and toolbox developed. This dimension includes making an inventory of implementation issues and drivers to tackle implementation barriers.